Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature
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چکیده
منابع مشابه
Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature.
The aberrant vascular architecture of solid tumors results in hypoxia that limits the efficacy of radiotherapy. Vascular normalization using antiangiogenic agents has been proposed as a means to improve radiation therapy by enhancing tumor oxygenation, but only short-lived effects for this strategy have been reported so far. Here, we show that NVP-BEZ235, a dual inhibitor of phosphoinositide-3-...
متن کاملDual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature Full author names
Running Title Vascular normalization by PI3K/mTOR inhibitors Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. ABSTRACT The aberrant vascular architecture of solid tumors results in hypoxia that limits the efficacy of radiotherapy. Vascular normalization using anti-angiogenic agents has been proposed as a means to improve radiation therapy by ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2011
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-11-2263